http://tcm-toxic.kmu.edu.tw/index.php?action=history&feed=atom&title=Depakene_%28valproic_acid%29_%E4%B8%AD%E6%AF%92 2026-07-25T18:32:21Z 本站上此頁的修訂歷史 MediaWiki 1.16.2 http://tcm-toxic.kmu.edu.tw/index.php?title=Depakene_(valproic_acid)_%E4%B8%AD%E6%AF%92&diff=2331&oldid=prev 2012-07-05T02:54:03Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←上一修訂</td> <td colspan='2' style="background-color: white; color:black;">在2012年7月5日 (四) 02:54所做的修訂版本</td> </tr><tr><td colspan="2" class="diff-lineno">第1行：</td> <td colspan="2" class="diff-lineno">第1行：</td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;font size=5 color=green&gt;1. Depakene 中毒機轉&lt;/font&gt; &lt;font size=4&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*1) 增加腦中的 GABA 含量或抑制 GABA 的回收，抑制腦部的抽搐活動及中樞神經的抑制</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*2) 肝臟毒性： 黃疸、肝功能異常、高氨血症 、致死</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/font&gt;</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;font size=5 color=green&gt;2. Depakene (valproic acid) 中毒症狀&lt;/font&gt; &lt;font size=4&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*1) 1,800mg 或濃度達 100μg/ml ：輕度的中樞神經抑制</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*2) 200mg/Kg ：嚴重的昏迷、呼吸抑制、QTc 間隔延長、血壓降低、反射降低、代謝性酸中毒、肝腎功能異常、高氨血症、血小板降低、高鈉血症、低鈣血症、貧血、白血球降低、胰臟炎、腦水腫、甚至死亡</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*3) 慢性中毒者： 骨髓抑制、胰臟炎、肝炎、腸胃不適</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/font&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;font size=5 color=green&gt;3. Depakene (valproic acid) 中毒治療&lt;/font&gt; &lt;font size=4&gt;</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*1) 洗胃、活性碳灌洗、支持性療法，但不催吐</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*2) 呼吸抑制：氣管插管</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*3) 低血壓： 補充水份、升壓劑</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*4) 血液透析</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*5) 腦水腫：降腦壓藥物</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*6) 胰臟炎： 補充水份、注意營養狀態</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*7) 肝功能異常： 注意凝血機能、營養狀況的矯正</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">*8) 追蹤血中濃度 &gt;.100μg/ml 中毒，本院毒藥物諮詢檢驗中心可檢測</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">&lt;/font&gt;</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://tcm-toxic.kmu.edu.tw/index.php/%E5%B8%B8%E8%A6%8B%E4%B8%AD%E6%AF%92%E8%99%95%E7%90%86%E6%96%B9%E5%BC%8F 返回常見中毒處理方式]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[http://tcm-toxic.kmu.edu.tw/index.php/%E5%B8%B8%E8%A6%8B%E4%B8%AD%E6%AF%92%E8%99%95%E7%90%86%E6%96%B9%E5%BC%8F 返回常見中毒處理方式]</div></td></tr> </table>

Kmutox520 http://tcm-toxic.kmu.edu.tw/index.php?title=Depakene_(valproic_acid)_%E4%B8%AD%E6%AF%92&diff=2324&oldid=prev 2012-07-05T02:29:45Z

<p>以內容「 [http://tcm-toxic.kmu.edu.tw/index.php/%E5%B8%B8%E8%A6%8B%E4%B8%AD%E6%AF%92%E8%99%95%E7%90%86%E6%96%B9%E5%BC%8F 返回常見中毒處理方式]」創建新頁面</p> <p><b>新頁面</b></p><div><br /> <br /> <br /> [http://tcm-toxic.kmu.edu.tw/index.php/%E5%B8%B8%E8%A6%8B%E4%B8%AD%E6%AF%92%E8%99%95%E7%90%86%E6%96%B9%E5%BC%8F 返回常見中毒處理方式]</div>

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