香桂 - 修訂歷史

Kmutox520在2012年7月3日 (二) 09:32

2012-07-03T09:32:42Z

Kmutox520: /* 毒性研究 */

2012-02-29T01:28:41Z

毒性研究

←上一修訂		在2012年2月29日 (三) 01:28所做的修訂版本
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	*<font size=3, color=green>'''機轉'''</font>		*<font size=3, color=green>'''機轉'''</font>
-	<font size=3>Chen et al.於2007年自葉部分離出isoobtusilactone A，然後利用HepG2細胞株來進行體外的毒性測試，結果發現isoobtusilactone A可引起劑量相關性的細胞生長抑制，半數抑制劑量IC50為37.5 microM，同時也發現isoobtusilactone A可促進細胞的sub-G1數量及DNA斷裂增多，粒線體膜外cytochrome c濃度也上升導致caspase 3被活化及PARP cleavage而促使細胞凋亡；但在動物實驗中給予350及700 mg/kg的isoobtusilactone A給予5-6週大的Sprague Dawley老鼠，並沒有發現明顯的動物毒性[9]。Liu et al.及Wang et al.~~兩組人於2011年分別各以Subamolide~~ A及E測試其對細胞的毒性，Liu發現subamolide A可促進NTBU1細胞的粒線體改變，透過活化p53及ERK1/2引起細胞凋亡[10]；而Wang則發現subamolide E則可影響A375.S2細胞的生長週期，提高sub-G1期的數量，並且透過活化caspase 3, 6, 7, 9及PARP而導致細胞凋亡[11]。</font>	+	<font size=3>Chen et al.於2007年自葉部分離出isoobtusilactone A，然後利用HepG2細胞株來進行體外的毒性測試，結果發現isoobtusilactone A可引起劑量相關性的細胞生長抑制，半數抑制劑量IC50為37.5 microM，同時也發現isoobtusilactone A可促進細胞的sub-G1數量及DNA斷裂增多，粒線體膜外cytochrome c濃度也上升導致caspase 3被活化及PARP cleavage而促使細胞凋亡；但在動物實驗中給予350及700 mg/kg的isoobtusilactone A給予5-6週大的Sprague Dawley老鼠，並沒有發現明顯的動物毒性[9]。Liu et al.及Wang et al.於2011年分別各以Subamolide A及E測試其對細胞的毒性，Liu發現subamolide A可促進NTBU1細胞的粒線體改變，透過活化p53及ERK1/2引起細胞凋亡[10]；而Wang則發現subamolide E則可影響A375.S2細胞的生長週期，提高sub-G1期的數量，並且透過活化caspase 3, 6, 7, 9及PARP而導致細胞凋亡[11]。</font>

	*<font size=3, color=green>'''毒性成分'''</font>		*<font size=3, color=green>'''毒性成分'''</font>

Kmutox520: /* 植物圖片 */

2011-12-17T18:55:47Z

植物圖片

←上一修訂		在2011年12月17日 (六) 18:55所做的修訂版本
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-	[[檔案:香桂01.JPG\|~~300px~~\|香桂全株]]	+	[[檔案:香桂01.JPG\|200px\|香桂全株]]

	香桂全株		香桂全株
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	:香桂花苞2		:香桂花苞2
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	== '''香桂簡介''' ==		== '''香桂簡介''' ==

Kmutox520: /* 參考文獻 */

2011-12-04T13:52:07Z

參考文獻

←上一修訂		在2011年12月4日 (日) 13:52所做的修訂版本
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	1. Kojima H, Sato N, Hatano A, Ogura H. [http://www.sciencedirect.com/science/article/pii/003194229083073A Sterol glucosides from ''Prunella vulgaris''.] ''Phytochemistry'' 1990; 29: 2351-2355.		1. Kojima H, Sato N, Hatano A, Ogura H. [http://www.sciencedirect.com/science/article/pii/003194229083073A Sterol glucosides from ''Prunella vulgaris''.] ''Phytochemistry'' 1990; 29: 2351-2355.

-	2. LI J, ~~KADOTA~~ S, ~~KAWATA~~ Y, ~~HATTORI~~ M, XU GJ, ~~NAMBA~~ T. [http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=cpb1958&cdvol=40&noissue=12&startpage=3133 Constituents of the roots of ''Cynanchum bungei'' DECNE.isolation and structures of four new glucosides, bunngeiside-A, -B, -C, and -D.] ''Chemical & Pharmaceutical Bulletin'' 1992; 40: 3133-3137.	+	2. Li J, Kadota S, Kawta Y, Hattori M, Xu GJ, Namba T. [http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=cpb1958&cdvol=40&noissue=12&startpage=3133 Constituents of the roots of ''Cynanchum bungei'' DECNE.isolation and structures of four new glucosides, bunngeiside-A, -B, -C, and -D.] ''Chemical & Pharmaceutical Bulletin'' 1992; 40: 3133-3137.

	3. Cheng M-J, Tsai I-L, Chen I-S. [http://www.airiti.com/ceps/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=3598&issueiid=62770&atliid=1065797 Chemical constituents from ''Strychnos cathayensis''.] ''Journal of the Chinese Chemical Society'' 2001; 48: 235-240.		3. Cheng M-J, Tsai I-L, Chen I-S. [http://www.airiti.com/ceps/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=3598&issueiid=62770&atliid=1065797 Chemical constituents from ''Strychnos cathayensis''.] ''Journal of the Chinese Chemical Society'' 2001; 48: 235-240.
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	8. Shen KH, Lin ES, Kuo PL, Chen CY, Hsu YL. [http://www.ncbi.nlm.nih.gov/pubmed/21196431 Isolinderanolide B, a butanolide extracted from the stems of ''Cinnamomum subavenium'', inhibits proliferation of T24 human bladder cancer cells by blocking cell cycle progression and inducing Apoptosis.] ''Integrative Cancer Therapies'' 2010.		8. Shen KH, Lin ES, Kuo PL, Chen CY, Hsu YL. [http://www.ncbi.nlm.nih.gov/pubmed/21196431 Isolinderanolide B, a butanolide extracted from the stems of ''Cinnamomum subavenium'', inhibits proliferation of T24 human bladder cancer cells by blocking cell cycle progression and inducing Apoptosis.] ''Integrative Cancer Therapies'' 2010.

-	9. Chen ~~C-Y~~, Liu ~~T-Z~~, Chen ~~C-H~~, Wu ~~C-C~~, Cheng ~~J-T~~, Yiin ~~S-J~~, Shih ~~M-K~~, Wu ~~M-J~~, Chern ~~C-L~~. [http://www.ncbi.nlm.nih.gov/pubmed/17321026 Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.] ''Food and Chemical Toxicology'' 2007; 45: 1268-1276.	+	9. Chen CY, Liu TZ, Chen CH, Wu CC, Cheng JT, Yiin SJ, Shih MK, Wu MJ, Chern CL. [http://www.ncbi.nlm.nih.gov/pubmed/17321026 Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.] ''Food and Chemical Toxicology'' 2007; 45: 1268-1276.

	10. Liu CH, Chen CY, Huang AM, Li JH. [http://www.sciencedirect.com/science/article/pii/S0378874111004181 Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.] ''Journal of Ethnopharmacology'' 2011; 137: 503-511.		10. Liu CH, Chen CY, Huang AM, Li JH. [http://www.sciencedirect.com/science/article/pii/S0378874111004181 Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.] ''Journal of Ethnopharmacology'' 2011; 137: 503-511.

Kmutox520: /* 參考文獻 */

2011-12-04T13:50:45Z

參考文獻

←上一修訂		在2011年12月4日 (日) 13:50所做的修訂版本
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	== '''參考文獻''' ==		== '''參考文獻''' ==

-	1. Kojima H, Sato N, Hatano A, Ogura H. [http://www.sciencedirect.com/science/article/pii/003194229083073A Sterol glucosides from Prunella vulgaris.] ''Phytochemistry'' 1990; 29: 2351-2355.	+	1. Kojima H, Sato N, Hatano A, Ogura H. [http://www.sciencedirect.com/science/article/pii/003194229083073A Sterol glucosides from ''Prunella vulgaris''.] ''Phytochemistry'' 1990; 29: 2351-2355.

-	2. LI J, KADOTA S, KAWATA Y, HATTORI M, XU GJ, NAMBA T. [http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=cpb1958&cdvol=40&noissue=12&startpage=3133 Constituents of the ~~Roots~~ of Cynanchum bungei DECNE.~~Isolation~~ and ~~Structures~~ of ~~Four New Glucosides~~, ~~Bunngeiside~~-A, -B, -C, and -D.] ''Chemical & Pharmaceutical Bulletin'' 1992; 40: 3133-3137.	+	2. LI J, KADOTA S, KAWATA Y, HATTORI M, XU GJ, NAMBA T. [http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=cpb1958&cdvol=40&noissue=12&startpage=3133 Constituents of the roots of ''Cynanchum bungei'' DECNE.isolation and structures of four new glucosides, bunngeiside-A, -B, -C, and -D.] ''Chemical & Pharmaceutical Bulletin'' 1992; 40: 3133-3137.

-	3. Cheng M-J, Tsai I-L, Chen I-S. [http://www.airiti.com/ceps/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=3598&issueiid=62770&atliid=1065797 Chemical ~~Constituents~~ from Strychnos cathayensis.] ''Journal of the Chinese Chemical Society'' 2001; 48: 235-240.	+	3. Cheng M-J, Tsai I-L, Chen I-S. [http://www.airiti.com/ceps/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=3598&issueiid=62770&atliid=1065797 Chemical constituents from ''Strychnos cathayensis''.] ''Journal of the Chinese Chemical Society'' 2001; 48: 235-240.

-	4. Chen CH, Lo WL, Liu YC, Chen CY. [http://www.ncbi.nlm.nih.gov/pubmed/16792412 Chemical and cytotoxic constituents from the leaves of Cinnamomum kotoense.] ''Journal of Natural Products'' 2006; 69: 927-933.	+	4. Chen CH, Lo WL, Liu YC, Chen CY. [http://www.ncbi.nlm.nih.gov/pubmed/16792412 Chemical and cytotoxic constituents from the leaves of ''Cinnamomum kotoense''.] ''Journal of Natural Products'' 2006; 69: 927-933.

-	5. Chen CY, Chen CH, Wong CH, Liu YW, Lin YS, Wang YD, Hsui YR. [http://www.ncbi.nlm.nih.gov/pubmed/18175985 Cytotoxic constituents of the stems of Cinnamomum subavenium.] ''Journal of Natural Products'' 2007; 70: 103-106.	+	5. Chen CY, Chen CH, Wong CH, Liu YW, Lin YS, Wang YD, Hsui YR. [http://www.ncbi.nlm.nih.gov/pubmed/18175985 Cytotoxic constituents of the stems of ''Cinnamomum subavenium''.] ''Journal of Natural Products'' 2007; 70: 103-106.

-	6. Lin RJ, Lo WL, Wang YD, Chen CY. [http://www.ncbi.nlm.nih.gov/pubmed/18780246 A novel cytotoxic monoterpenoid from the leaves of Cinnamomum subavenium.] ''Natural Product Reseach'' 2008; 22: 1055-1059.	+	6. Lin RJ, Lo WL, Wang YD, Chen CY. [http://www.ncbi.nlm.nih.gov/pubmed/18780246 A novel cytotoxic monoterpenoid from the leaves of ''Cinnamomum subavenium''.] ''Natural Product Reseach'' 2008; 22: 1055-1059.

-	7. Chen CY, Yang WL, Hsui YR. [http://www.ncbi.nlm.nih.gov/pubmed/20306364 A novel sesquiterpenoid from the roots of Cinnamomum subavenium.] ''Natural Product Reseach'' 2010; 24: 423-427.	+	7. Chen CY, Yang WL, Hsui YR. [http://www.ncbi.nlm.nih.gov/pubmed/20306364 A novel sesquiterpenoid from the roots of ''Cinnamomum subavenium''.] ''Natural Product Reseach'' 2010; 24: 423-427.

-	8. Shen KH, Lin ES, Kuo PL, Chen CY, Hsu YL. [http://www.ncbi.nlm.nih.gov/pubmed/21196431 Isolinderanolide B, a ~~Butanolide Extracted From~~ the ~~Stems~~ of Cinnamomum subavenium, ~~Inhibits Proliferation~~ of T24 ~~Human Bladder Cancer Cells~~ by ~~Blocking Cell Cycle Progression~~ and ~~Inducing~~ Apoptosis.] ''Integrative Cancer Therapies'' 2010.	+	8. Shen KH, Lin ES, Kuo PL, Chen CY, Hsu YL. [http://www.ncbi.nlm.nih.gov/pubmed/21196431 Isolinderanolide B, a butanolide extracted from the stems of ''Cinnamomum subavenium'', inhibits proliferation of T24 human bladder cancer cells by blocking cell cycle progression and inducing Apoptosis.] ''Integrative Cancer Therapies'' 2010.

	9. Chen C-Y, Liu T-Z, Chen C-H, Wu C-C, Cheng J-T, Yiin S-J, Shih M-K, Wu M-J, Chern C-L. [http://www.ncbi.nlm.nih.gov/pubmed/17321026 Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.] ''Food and Chemical Toxicology'' 2007; 45: 1268-1276.		9. Chen C-Y, Liu T-Z, Chen C-H, Wu C-C, Cheng J-T, Yiin S-J, Shih M-K, Wu M-J, Chern C-L. [http://www.ncbi.nlm.nih.gov/pubmed/17321026 Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.] ''Food and Chemical Toxicology'' 2007; 45: 1268-1276.

Kmutox520: /* 毒性分級 */

2011-12-04T13:44:56Z

毒性分級

←上一修訂		在2011年12月4日 (日) 13:44所做的修訂版本
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	=='''毒性分級'''==		=='''毒性分級'''==
-	<font size=3>[http://tcm-toxic.kmu.edu.tw/index.php/%E6%AF%92%E6%80%A7%E5%88%86%E9%A1%9E ~~級數D~~]</font>	+	<font size=3>[http://tcm-toxic.kmu.edu.tw/index.php/%E6%AF%92%E6%80%A7%E5%88%86%E9%A1%9E 級數C2]</font>
-		+

	== '''參考文獻''' ==		== '''參考文獻''' ==

Kmutox520: /* 參考文獻 */

2011-12-04T13:20:50Z

參考文獻

←上一修訂		在2011年12月4日 (日) 13:20所做的修訂版本
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	3. Cheng M-J, Tsai I-L, Chen I-S. [http://www.airiti.com/ceps/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=3598&issueiid=62770&atliid=1065797 Chemical Constituents from Strychnos cathayensis.] ''Journal of the Chinese Chemical Society'' 2001; 48: 235-240.		3. Cheng M-J, Tsai I-L, Chen I-S. [http://www.airiti.com/ceps/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=3598&issueiid=62770&atliid=1065797 Chemical Constituents from Strychnos cathayensis.] ''Journal of the Chinese Chemical Society'' 2001; 48: 235-240.

-	4. Chen CH, Lo WL, Liu YC, Chen CY. [www.ncbi.nlm.nih.gov/pubmed/16792412 Chemical and cytotoxic constituents from the leaves of Cinnamomum kotoense.] ''Journal of Natural Products'' 2006; 69: 927-933.	+	4. Chen CH, Lo WL, Liu YC, Chen CY. [http://www.ncbi.nlm.nih.gov/pubmed/16792412 Chemical and cytotoxic constituents from the leaves of Cinnamomum kotoense.] ''Journal of Natural Products'' 2006; 69: 927-933.

	5. Chen CY, Chen CH, Wong CH, Liu YW, Lin YS, Wang YD, Hsui YR. [http://www.ncbi.nlm.nih.gov/pubmed/18175985 Cytotoxic constituents of the stems of Cinnamomum subavenium.] ''Journal of Natural Products'' 2007; 70: 103-106.		5. Chen CY, Chen CH, Wong CH, Liu YW, Lin YS, Wang YD, Hsui YR. [http://www.ncbi.nlm.nih.gov/pubmed/18175985 Cytotoxic constituents of the stems of Cinnamomum subavenium.] ''Journal of Natural Products'' 2007; 70: 103-106.

Kmutox520在2011年12月4日 (日) 13:19

2011-12-04T13:19:24Z

←上一修訂		在2011年12月4日 (日) 13:19所做的修訂版本
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	__NOTOC__		__NOTOC__
-	[http://tcm-toxic.kmu.edu.tw/index.php/%E8%8F%~~8A_~~%E7%A7%91 返回上一頁]	+	[http://tcm-toxic.kmu.edu.tw/index.php/%E6%A8%9F%E7%A7%91 返回上一頁]

	== '''基本資料''' ==		== '''基本資料''' ==
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-	[http://tcm-toxic.kmu.edu.tw/index.php/%E8%8F%~~8A_~~%E7%A7%91 返回上一頁]	+	[http://tcm-toxic.kmu.edu.tw/index.php/%E6%A8%9F%E7%A7%91 返回上一頁]

Kmutox520: /* 毒性研究 */

2011-12-04T13:18:06Z

毒性研究

←上一修訂		在2011年12月4日 (日) 13:18所做的修訂版本
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	*Subamolide A[10]		*Subamolide A[10]
	*Subamolide E[11]		*Subamolide E[11]
-	~~</font>~~
-
-	*<font size=3, color=green>'''中毒劑量'''</font>
-	~~<font size=3>~~
-
	</font>		</font>

Kmutox520: /* 毒性研究 */

2011-12-04T13:17:49Z

毒性研究

←上一修訂		在2011年12月4日 (日) 13:17所做的修訂版本
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	*<font size=3, color=green>'''毒性成分'''</font>		*<font size=3, color=green>'''毒性成分'''</font>
	<font size=3>		<font size=3>
-	*isoobtusilactone A	+	*isoobtusilactone A[9]
-	*Subamolide A	+	*Subamolide A[10]
-	*Subamolide E	+	*Subamolide E[11]
	</font>		</font>