守宮木 - 修訂歷史

Kmutox520在2012年7月3日 (二) 17:24

2012-07-03T17:24:44Z

Kmutox520在2012年6月11日 (一) 00:57

2012-06-11T00:57:50Z

←上一修訂		在2012年6月11日 (一) 00:57所做的修訂版本
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	__NOTOC__		__NOTOC__
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-	{{:模板:基本資料\|1=大戟科 Euphorbiaceae\|2=守宮木屬\|3= 'Sauropus'\|4=守宮木\|5=''Sauropus ~~androgynus”~~ (Linn.) Merr.\|6=Pak-Waan-Bann, Katuk, asin-asin, Chekor manis \|7=減肥菜、剪肥菜、樹仔菜、越南菜、沙巴菜}}	+	{{:模板:基本資料\|1=大戟科 Euphorbiaceae\|2=守宮木屬\|3= 'Sauropus'\|4=守宮木\|5=''Sauropus androgynus'' (Linn.) Merr.\|6=Pak-Waan-Bann, Katuk, asin-asin, Chekor manis \|7=減肥菜、剪肥菜、樹仔菜、越南菜、沙巴菜}}

Kmutox520在2012年6月4日 (一) 08:16

2012-06-04T08:16:20Z

←上一修訂		在2012年6月4日 (一) 08:16所做的修訂版本
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	守宮木葉		守宮木葉
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	== '''守宮木簡介''' ==		== '''守宮木簡介''' ==

Kmutox520: /* 植物圖片 */

2012-06-04T08:16:03Z

植物圖片

←上一修訂		在2012年6月4日 (一) 08:16所做的修訂版本
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	== '''守宮木簡介''' ==		== '''守宮木簡介''' ==

Kmutox520: /* 毒性分級 */

2012-06-04T07:50:22Z

毒性分級

←上一修訂		在2012年6月4日 (一) 07:50所做的修訂版本
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	=='''毒性分級'''==		=='''毒性分級'''==
-	<font size=3>[http://tcm-toxic.kmu.edu.tw/index.php/%E6%AF%92%E6%80%A7%E5%88%86%E9%A1%9E 級數B]</font>	+	<font size=3>[http://tcm-toxic.kmu.edu.tw/index.php/%E6%AF%92%E6%80%A7%E5%88%86%E9%A1%9E 級數B, 等級2]</font>
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	== '''參考文獻''' ==		== '''參考文獻''' ==

Kmutox520: /* 毒性研究 */

2012-06-04T07:48:19Z

毒性研究

←上一修訂		在2012年6月4日 (一) 07:48所做的修訂版本
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	*<font size=3 color=green>'''肺臟毒性'''</font> <font size=3>		*<font size=3 color=green>'''肺臟毒性'''</font> <font size=3>
	**1. 經由分析得知守宮木葉的成分含有高量的papaverine[2]，實驗分別口服給予Sprague-Dawley大鼠守宮木葉及papaverine的1倍，10倍及20倍的濃縮液，另外也以腹腔注射給予5及10倍的papaverine濃縮液，均無發現大鼠有任何肺部纖維化的現象，僅有輕微的發炎現象。此種結果可能因為是物種間的不同，而與臨床案例有不同的結果[12]。		**1. 經由分析得知守宮木葉的成分含有高量的papaverine[2]，實驗分別口服給予Sprague-Dawley大鼠守宮木葉及papaverine的1倍，10倍及20倍的濃縮液，另外也以腹腔注射給予5及10倍的papaverine濃縮液，均無發現大鼠有任何肺部纖維化的現象，僅有輕微的發炎現象。此種結果可能因為是物種間的不同，而與臨床案例有不同的結果[12]。
-	**2. 病患在連續服用守宮木後，總累積較高劑量(≥7200 g)的病患，所產生的阻塞性換氣障礙(obstructive ventilatory defect)的比率(13位, 48.1%)較低劑量(0-1799 g)的病患(4位, 9.3%)高。且在總試驗者當中有25.6% (49位)受試者罹患了中等至嚴重不同程度的阻塞性換氣障礙，且對支氣管擴張劑治療無反應，這49位當中又有65%的人在食用後7個月內，都產呼吸困難(dyspnea)~~的症狀，這些症狀在22個月的追蹤期內，都無法~~	+	**2. 病患在連續服用守宮木後，總累積較高劑量(≥7200 g)的病患，所產生的阻塞性換氣障礙(obstructive ventilatory defect)的比率(13位, 48.1%)較低劑量(0-1799 g)的病患(4位, 9.3%)高。且在總試驗者當中有25.6% (49位)受試者罹患了中等至嚴重不同程度的阻塞性換氣障礙，且對支氣管擴張劑治療無反應，這49位當中又有65%的人在食用後7個月內，都產呼吸困難(dyspnea)的症狀，這些症狀在22個月的追蹤期內，都無法自行回復[13]。
	**3. 在食用守宮木，且出現呼吸道症狀的病患的肺部組織病理切片染色可觀察到T細胞的表現量遠高於B細胞，而血液中的腫瘤壞死因子alpha (TNF-α)也相對正常人明顯的上升。對於藥物(prednisolone及bronchodilator)的治療沒有顯著反應[14]。		**3. 在食用守宮木，且出現呼吸道症狀的病患的肺部組織病理切片染色可觀察到T細胞的表現量遠高於B細胞，而血液中的腫瘤壞死因子alpha (TNF-α)也相對正常人明顯的上升。對於藥物(prednisolone及bronchodilator)的治療沒有顯著反應[14]。
	</font>		</font>
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	*<font size=3 color=green>'''基因毒性'''</font> <font size=3>		*<font size=3 color=green>'''基因毒性'''</font> <font size=3>
	**1. 守宮木萃取液給予中國倉鼠肺成纖維細胞(CHL)及中國倉鼠肺細胞(V79)，發現50%的守宮木萃取液在CHL上，未經肝臟酵素代謝會對CHL產生極為明顯的染色體突變[16]。</font>		**1. 守宮木萃取液給予中國倉鼠肺成纖維細胞(CHL)及中國倉鼠肺細胞(V79)，發現50%的守宮木萃取液在CHL上，未經肝臟酵素代謝會對CHL產生極為明顯的染色體突變[16]。</font>
-

	=='''毒性分級'''==		=='''毒性分級'''==

Kmutox520: /* 參考文獻 */

2012-06-04T07:43:05Z

參考文獻

←上一修訂		在2012年6月4日 (一) 07:43所做的修訂版本
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	15. Yu SF, Chen TM, Chen YH. [http://www.ncbi.nlm.nih.gov/pubmed/17660143 Apoptosis and necrosis are involved in the toxicity of Sauropus androgynus in an in vitro study.] ''Journal of the Formosan Medical Association'' 2007; 106: 537-547.		15. Yu SF, Chen TM, Chen YH. [http://www.ncbi.nlm.nih.gov/pubmed/17660143 Apoptosis and necrosis are involved in the toxicity of Sauropus androgynus in an in vitro study.] ''Journal of the Formosan Medical Association'' 2007; 106: 537-547.

-	16. 張靜, 熊習昆, 楊穎, 王京濱, 陳秀娟. [http://www.ceps.com.tw/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=1548&issueiid=80165&atliid=1546605 守宮木致CHL及V79細胞染色體畸變作用.] 中國公共衛生 2009; 25: 327-329.	+	16. 張靜, 熊習昆, 楊穎, 王京濱, 陳秀娟. [http://www.ceps.com.tw/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=1548&issueiid=80165&atliid=1546605 守宮木致CHL及V79細胞染色體畸變作用.] ''中國公共衛生'' 2009; 25: 327-329.
	</font>		</font>


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Kmutox520: /* 參考文獻 */

2012-06-04T07:42:48Z

參考文獻

Kmutox520: /* 參考文獻 */

2012-06-04T07:30:09Z

參考文獻

←上一修訂		在2012年6月4日 (一) 07:30所做的修訂版本
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	== '''參考文獻''' ==		== '''參考文獻''' ==
	<font size=3>		<font size=3>
-	1. ~~Maheswari JK~~, ~~Singh K~~, ~~Shah S~~. [http://~~indianmedicine~~.~~eldoc~~.ub.~~rug.nl~~/~~root~~/~~M/65433/ Ethanomedicinal uses of plants by the Tharus of Kheri District, U.P~~.] ''~~Bulletin of Medico-Ethno-Botanical Research~~'' ~~1980~~; 1: ~~318~~-~~337~~.	+	1. 林增記, 江大雄, 謝義山, 李明儀, 陳俊達, 陳宏吉, 施怡如, 許世昌, 鄧昭芳. [http://www.ceps.com.tw/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=483&issueiid=2793&atliid=24139 減肥菜之中毒事件]. ''疫情報導'' 1996; 12: 68-73.

-	2. ~~Singh RH~~, ~~Singhal KC, Khan NU~~. ~~[http://indianmedicine.eldoc.ub.rug.nl/root/S/116446/ Antifilarial activity~~ of ~~Mallotus philippensis Lam~~. ~~on Setaria cervi (nematode: Filaroidea) in vitro.] ''Indian Journal of Physiology and Pharmacology'' 1997~~; 41: ~~397-~~-~~403~~.	+	2. Padmavathi P, Rao MP. Nutritive value of Sauropus androgynus leaves. Plant foods for human nutrition 1990; 40: 107-113.

-	3. ~~Taylor RS~~, ~~Edel F~~, ~~Manandhar NP~~, ~~Towers GH~~. ~~[http://www.sciencedirect.com/science/article/pii/0378874195013350 Antimicrobial activities~~ of ~~southern Nepalese medicinal plants~~.~~] ''Journal of Ethnopharmacology'' 1996~~; 50: 97-~~102~~.	+	3. Sawahata M, Ogura T, Tagawa A, Takahashi H, Yazawa T, Matsuura M, Takemura T. Sauropus androgynus-associated bronchiolitis obliterans of mother and daughter – autopsy report. Respiratory Medicine CME 2010; 3: 214-217.

-	4. ~~Srivastava MC~~, ~~Singh SW~~, ~~Tewari JP~~. ~~[http~~:~~//indianmedicine~~.~~eldoc.ub.rug.nl/root/S2/445s/ Anthelmintic activity of Mallotus philippinensis (kampila) powder.] ''Indian Journal of Medical Research'' 1967~~; 55: ~~746~~-~~748~~.	+	4. Ger LP, Chiang AA, Lai RS, Chen SM, Tseng CJ. Association of Sauropus androgynus and bronchiolitis obliterans syndrome: a hospital-based case-control study. Am J Epidemiol 1997; 145: 842-849.

-	5. ~~Gupta SS~~, ~~Verma P~~, ~~Hishikar~~ K. ~~[http://www.ncbi.nlm.nih.gov/pubmed/6490133 Purgative and anthelmintic effects~~ of ~~Mallotus philippinensis~~ in ~~rats against tape worm.] Indian ''Journal~~ of ~~Physiology and Pharmacology'' 1984~~; 28: ~~63-66~~.	+	5. Oonakahara K, Matsuyama W, Higashimoto I, Machida K, Kawabata M, Arimura K, Osame M, Hayashi M, Ogura T, Imaizumi K, Hasegawa Y. Outbreak of Bronchiolitis obliterans associated with consumption of Sauropus androgynus in Japan--alert of food-associated pulmonary disorders from Japan. Respiration 2005; 72: 221.

-	6. ~~Daikonya A~~, ~~Katsuki S~~, Wu ~~J-B~~, ~~Kitanaka S~~. ~~[http://www.ncbi.nlm.nih.gov/pubmed/12499591 Anti~~-~~allergic Agents from Natural Sources (4): Anti~~-~~allergic Activity of New Phloroglucinol Derivatives from Mallotus philippensis~~ (~~Euphorbiaceae~~).~~] ''Chemical & Pharmaceutical Bulletin'' 2002~~; 50: ~~1566~~-~~1569~~.	+	6. Luh SP, Lee YC, Chang YL, Wu HD, Kuo SH, Chu SH. Lung transplantation for patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome. Clin Transplant 1999; 13: 496-503.

-	7. ~~Gschwendt M~~, ~~Muller HJ~~, ~~Kielbassa K, Zang~~ R, ~~Kittstein W~~, ~~Rincke G, Marks F~~. ~~[http://www~~.~~ncbi.nlm.nih.gov/pubmed/8123051 Rottlerin, a novel protein kinase inhibitor.] ''Biochemical and Biophysical Research Communications'' 1994~~; ~~199~~: 93-98.	+	7. Kanchanapoom T, Chumsri P, Kasai R, Otsuka H, Yamasaki K. Lignan and megastigmane glycosides from Sauropus androgynus. Phytochemistry 2003; 63: 985-988.

-	8. ~~Gujral ML~~, ~~Varma DR~~, ~~Sareen KN. [http://www.ncbi.nlm.nih.gov/pubmed/13830235 Oral contraceptives. Part I. Preliminary observations on the antifertility effect~~ of ~~some indigenous drugs~~.~~] ''Indian Journal of Medical Research'' 1960~~; 48: 46-51.	+	8. Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 2001; 49: 3106-3112.

-	9. ~~Gujral ML~~, ~~Varma DR~~, ~~Sareen KN~~, ~~Roy AK~~. ~~[http://www.ncbi.nlm.nih.gov/pubmed/13830236 Oral contraceptives. Part II. Antifertility effect~~ of ~~Mallotus philippinensis Mueller-argoviensis~~.~~] ''Indian Journal of Medical Research'' 1960~~; 48: 52-58.	+	9. Andarwulan N, Batari R, Sandrasari DA, Bolling B, Wijaya N. Flavonoid content and antioxidant activity of vegetables from Indonesia. Food Chemistry 2010; 121: 1231-1235.

-	10. ~~Thakur SC~~, ~~Thakur SS~~, ~~Chaube SK~~, ~~Singh SP~~. ~~[http://www.ncbi.nlm.nih.gov/pubmed/15808798 An etheral extract of Kamala~~ (~~Mallotus philippinensis (Moll.Arg~~) ~~Lam.) seed induce adverse effects on reproductive parameters of female~~ rats.~~] ''Reproductive Toxicology'' 2005~~; 20: ~~149~~-~~156~~.	+	10. Yu SF, Shun CT, Chen TM, Chen YH. 3-O-beta-D-glucosyl-(1-->6)-beta-D-glucosyl-kaempferol isolated from Sauropus androgenus reduces body weight gain in Wistar rats. Biological & pharmaceutical bulletin 2006; 29: 2510-2513.

-	11. ~~Smit HF~~, ~~Woerdenbag HJ~~, ~~Singh RH~~, ~~Meulenbeld GJ~~, ~~Labadie RP~~, ~~Zwaving JH~~. ~~[http~~:~~//www~~.~~ncbi~~.~~nlm~~.~~nih~~.~~gov/pubmed/7500639 Ayurvedic herbal drugs~~ with ~~possible cytostatic activity~~.~~] ''Journal~~ of ~~Ethnopharmacology'' 1995~~; 47: 75-84.	+	11. Soka S, Alam H, Boenjamin N, Agustina TW, Suhartono MT. Effect of Sauropus androgynus leaf extracts on the expression of prolactin and oxytocin genes in lactating BALB/C mice. J Nutrigenet Nutrigenomics 2010; 3: 31-36.
		+
		+	12. Lai RS, Wang JS, Lee PC. Sauropus androgynus and papaverine do not induce bronchiolitis obliterans in Sprague-Dawley rats. Zhonghua Yi Xue Za Zhi (Taipei) 2000; 63: 536-541.
		+
		+	13. Hsiue TR, Guo YL, Chen KW, Chen CW, Lee CH, Chang HY. Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus. Chest 1998; 113: 71-76.
		+
		+	14. Lai RS, Chiang AA, Wu MT, Wang JS, Lai NS, Lu JY, Ger LP, Roggli V. Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan. Lancet 1996; 348: 83-85.
		+
		+	15. Yu SF, Chen TM, Chen YH. Apoptosis and necrosis are involved in the toxicity of Sauropus androgynus in an in vitro study. J Formos Med Assoc 2007; 106: 537-547.
		+
		+	16. 張靜, 熊習昆, 楊穎, 王京濱, 陳秀娟. 守宮木致CHL及V79細胞染色體畸變作用. 中國公共衛生 2009; 25: 327-329.
	</font>		</font>


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Kmutox520在2012年6月4日 (一) 07:27

2012-06-04T07:27:17Z

←上一修訂		在2012年6月4日 (一) 07:27所做的修訂版本
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	*<font size=3 color=green>'''基因毒性'''</font> <font size=3>		*<font size=3 color=green>'''基因毒性'''</font> <font size=3>
	**1. 守宮木萃取液給予中國倉鼠肺成纖維細胞(CHL)及中國倉鼠肺細胞(V79)，發現50%的守宮木萃取液在CHL上，未經肝臟酵素代謝會對CHL產生極為明顯的染色體突變[16]。</font>		**1. 守宮木萃取液給予中國倉鼠肺成纖維細胞(CHL)及中國倉鼠肺細胞(V79)，發現50%的守宮木萃取液在CHL上，未經肝臟酵素代謝會對CHL產生極為明顯的染色體突變[16]。</font>
		+

	=='''毒性分級'''==		=='''毒性分級'''==

←上一修訂		在2012年6月4日 (一) 08:16所做的修訂版本
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	== '''守宮木簡介''' ==		== '''守宮木簡介''' ==

←上一修訂		在2012年6月4日 (一) 07:42所做的修訂版本
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	1. 林增記, 江大雄, 謝義山, 李明儀, 陳俊達, 陳宏吉, 施怡如, 許世昌, 鄧昭芳. [http://www.ceps.com.tw/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=483&issueiid=2793&atliid=24139 減肥菜之中毒事件]. ''疫情報導'' 1996; 12: 68-73.		1. 林增記, 江大雄, 謝義山, 李明儀, 陳俊達, 陳宏吉, 施怡如, 許世昌, 鄧昭芳. [http://www.ceps.com.tw/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=483&issueiid=2793&atliid=24139 減肥菜之中毒事件]. ''疫情報導'' 1996; 12: 68-73.

-	2. Padmavathi P, Rao MP. Nutritive value of Sauropus androgynus leaves. Plant foods for human nutrition 1990; 40: 107-113.	+	2. Padmavathi P, Rao MP. [http://www.ncbi.nlm.nih.gov/pubmed/2385571 Nutritive value of Sauropus androgynus leaves.] ''Plant foods for human nutrition'' 1990; 40: 107-113.

-	3. Sawahata M, Ogura T, Tagawa A, Takahashi H, Yazawa T, Matsuura M, Takemura T. Sauropus androgynus-associated bronchiolitis obliterans of mother and daughter – autopsy report. Respiratory Medicine CME 2010; 3: 214-217.	+	3. Sawahata M, Ogura T, Tagawa A, Takahashi H, Yazawa T, Matsuura M, Takemura T. [http://www.sciencedirect.com/science/article/pii/S1755001709001109 Sauropus androgynus-associated bronchiolitis obliterans of mother and daughter – autopsy report.] ''Respiratory Medicine CME'' 2010; 3: 214-217.

-	4. Ger LP, Chiang AA, Lai RS, Chen SM, Tseng CJ. Association of Sauropus androgynus and bronchiolitis obliterans syndrome: a hospital-based case-control study. ~~Am J Epidemiol~~ 1997; 145: 842-849.	+	4. Ger LP, Chiang AA, Lai RS, Chen SM, Tseng CJ. [http://aje.oxfordjournals.org/content/145/9/842.short Association of Sauropus androgynus and bronchiolitis obliterans syndrome: a hospital-based case-control study.] ''American Journal of Epidemiology'' 1997; 145: 842-849.

-	5. Oonakahara K, Matsuyama W, Higashimoto I, Machida K, Kawabata M, Arimura K, Osame M, Hayashi M, Ogura T, Imaizumi K, Hasegawa Y. Outbreak of Bronchiolitis obliterans associated with consumption of Sauropus androgynus in Japan--alert of food-associated pulmonary disorders from Japan. Respiration 2005; 72: 221.	+	5. Oonakahara K, Matsuyama W, Higashimoto I, Machida K, Kawabata M, Arimura K, Osame M, Hayashi M, Ogura T, Imaizumi K, Hasegawa Y. [http://www.ncbi.nlm.nih.gov/pubmed/15824537 Outbreak of Bronchiolitis obliterans associated with consumption of Sauropus androgynus in Japan--alert of food-associated pulmonary disorders from Japan.] ''Respiration'' 2005; 72: 221.

-	6. Luh SP, Lee YC, Chang YL, Wu HD, Kuo SH, Chu SH. Lung transplantation for patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome. ~~Clin Transplant~~ 1999; 13: 496-503.	+	6. Luh SP, Lee YC, Chang YL, Wu HD, Kuo SH, Chu SH. [http://www.ncbi.nlm.nih.gov/pubmed/10617240 Lung transplantation for patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome.] ''Clinical Transplantation'' 1999; 13: 496-503.

-	7. Kanchanapoom T, Chumsri P, Kasai R, Otsuka H, Yamasaki K. Lignan and megastigmane glycosides from Sauropus androgynus. Phytochemistry 2003; 63: 985-988.	+	7. Kanchanapoom T, Chumsri P, Kasai R, Otsuka H, Yamasaki K. [http://www.ncbi.nlm.nih.gov/pubmed/12895550 Lignan and megastigmane glycosides from Sauropus androgynus.] ''Phytochemistry'' 2003; 63: 985-988.

-	8. Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. ~~J Agric~~ Food ~~Chem~~ 2001; 49: 3106-3112.	+	8. Miean KH, Mohamed S. [http://www.ncbi.nlm.nih.gov/pubmed/11410016 Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants.] ''Journal of Agricultural and Food Chemistry'' 2001; 49: 3106-3112.

-	9. Andarwulan N, Batari R, Sandrasari DA, Bolling B, Wijaya N. Flavonoid content and antioxidant activity of vegetables from Indonesia. Food Chemistry 2010; 121: 1231-1235.	+	9. Andarwulan N, Batari R, Sandrasari DA, Bolling B, Wijaya N. [http://www.google.com/url?sa=t&rct=j&q=Flavonoid+content+and+antioxidant+activity+of+vegetables+from+Indonesia&source=web&cd=1&ved=0CFUQFjAA&url=http%3A%2F%2Fnaldc.nal.usda.gov%2Fdownload%2F41822%2FPDF&ei=-mPMT4rqJO-fmQXc2KzsDg&usg=AFQjCNHoo5errisnx1dIpbPunTnp3hfGBw&sig2=PnJM6Cn8qFS3RXTGb0MWDw Flavonoid content and antioxidant activity of vegetables from Indonesia]. ''Food Chemistry'' 2010; 121: 1231-1235.

-	10. Yu SF, Shun CT, Chen TM, Chen YH. 3-O-beta-D-glucosyl-(1-->6)-beta-D-glucosyl-kaempferol isolated from Sauropus androgenus reduces body weight gain in Wistar rats. Biological & pharmaceutical bulletin 2006; 29: 2510-2513.	+	10. Yu SF, Shun CT, Chen TM, Chen YH. [http://www.ncbi.nlm.nih.gov/pubmed/17142992 3-O-beta-D-glucosyl-(1-->6)-beta-D-glucosyl-kaempferol isolated from Sauropus androgenus reduces body weight gain in Wistar rats.] ''Biological & pharmaceutical bulletin'' 2006; 29: 2510-2513.

-	11. Soka S, Alam H, Boenjamin N, Agustina TW, Suhartono MT. Effect of Sauropus androgynus leaf extracts on the expression of prolactin and oxytocin genes in lactating BALB/C mice. ~~J Nutrigenet~~ Nutrigenomics 2010; 3: 31-36.	+	11. Soka S, Alam H, Boenjamin N, Agustina TW, Suhartono MT. [http://www.ncbi.nlm.nih.gov/pubmed/20798550 Effect of Sauropus androgynus leaf extracts on the expression of prolactin and oxytocin genes in lactating BALB/C mice.] ''Journal of Nutrigenetics and Nutrigenomics'' 2010; 3: 31-36.

-	12. Lai RS, Wang JS, Lee PC. Sauropus androgynus and papaverine do not induce bronchiolitis obliterans in Sprague-Dawley rats. Zhonghua Yi Xue Za Zhi (Taipei) 2000; 63: 536-541.	+	12. Lai RS, Wang JS, Lee PC. [http://www.ncbi.nlm.nih.gov/pubmed/10934806 Sauropus androgynus and papaverine do not induce bronchiolitis obliterans in Sprague-Dawley rats.] ''Zhonghua Yi Xue Za Zhi (Taipei)'' 2000; 63: 536-541.

-	13. Hsiue TR, Guo YL, Chen KW, Chen CW, Lee CH, Chang HY. Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus. Chest 1998; 113: 71-76.	+	13. Hsiue TR, Guo YL, Chen KW, Chen CW, Lee CH, Chang HY. [http://www.ncbi.nlm.nih.gov/pubmed/9440571 Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus.] ''Chest'' 1998; 113: 71-76.

-	14. Lai RS, Chiang AA, Wu MT, Wang JS, Lai NS, Lu JY, Ger LP, Roggli V. Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan. Lancet 1996; 348: 83-85.	+	14. Lai RS, Chiang AA, Wu MT, Wang JS, Lai NS, Lu JY, Ger LP, Roggli V. [http://www.ncbi.nlm.nih.gov/pubmed/8676721 Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan.] ''Lancet'' 1996; 348: 83-85.

-	15. Yu SF, Chen TM, Chen YH. Apoptosis and necrosis are involved in the toxicity of Sauropus androgynus in an in vitro study. ~~J Formos Med Assoc~~ 2007; 106: 537-547.	+	15. Yu SF, Chen TM, Chen YH. [http://www.ncbi.nlm.nih.gov/pubmed/17660143 Apoptosis and necrosis are involved in the toxicity of Sauropus androgynus in an in vitro study.] ''Journal of the Formosan Medical Association'' 2007; 106: 537-547.

-	16. 張靜, 熊習昆, 楊穎, 王京濱, 陳秀娟. 守宮木致CHL及V79細胞染色體畸變作用. 中國公共衛生 2009; 25: 327-329.	+	16. 張靜, 熊習昆, 楊穎, 王京濱, 陳秀娟. [http://www.ceps.com.tw/ec/ecjnlarticleView.aspx?jnlcattype=0&jnlptype=0&jnltype=0&jnliid=1548&issueiid=80165&atliid=1546605 守宮木致CHL及V79細胞染色體畸變作用.] 中國公共衛生 2009; 25: 327-329.
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